Document Type : Regular Article
Authors
1
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran. Department of Pharmaceutics, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
2
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3
Department of Pharmaceutics, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. Experimental and Applied Pharmaceutical Research Center, Urmia University of Medical Sciences, Urmia, Iran
4
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
10.22036/pcr.2024.404206.2366
Abstract
This work aimed to study the temperature dependant solubility of sulfasalazine (Sulf) in binary solutions of polyethylene glycol (PEG) 600 and 1,2, propanediol using the saturation shake flask method between 298.15 K and 313.15 K. Generally, sulf solubility increased with the elevation of temperature and mass fraction of the co-solvent. The highest drug solubility was observed in pure PEG-600 (56.67 ×10-3 mol L-1) while the lowest drug solubility was observed in pure water (0.14 ×10-3 mol L-1). Drug solubility in pure 1,2 propanediol was 3.56 ×10-3 mol L-1. The same results were observed at each temperature. Thermodynamic analysis indicates endothermic solubilization in aqueous mixtures in each of the investigated binary solvent mixtures. Overall, the findings of this work suggest that the various co-solvents could be used to solubilize poorly water-soluble drugs such as Sulf. The experimental solubility data of Sulf were regressed using the van’t, the mixture response surface, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff, and the modified Wilson models.
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